DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo

Author:

Thompson Karen J.1,Khajehali Elham2,Bradley Sophie J.1,Navarrete Jovana S.34,Huang Xi Ping5,Slocum Samuel5,Jin Jian6ORCID,Liu Jing6,Xiong Yan6,Olsen Reid H. J.5,Diberto Jeffrey F.5,Boyt Kristen M.5,Pina Melanie M.5,Pati Dipanwita5,Molloy Colin1,Bundgaard Christoffer7,Sexton Patrick M.2ORCID,Kash Thomas L.5,Krashes Michael J.34,Christopoulos Arthur2,Roth Bryan L.5,Tobin Andrew B.1ORCID

Affiliation:

1. Centre for Translational Pharmacology, Institute of Molecular, Cell, and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland G12 8QQ, United Kingdom

2. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

3. Diabetes, Endocrinology, and Obesity Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States

4. National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, United States

5. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina NC2751, United States

6. Center for Chemical Biology and Drug Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY10029, United States

7. Neuroscience, Eli Lilly & Co., Erl Wood Manor, Windlesham, Surrey GU20 6PH, United Kingdom

Funder

National Institute of Neurological Disorders and Stroke

Medical Research Council

National Institute of Diabetes and Digestive and Kidney Diseases

Wellcome Trust

University of Glasgow

National Institute of Mental Health

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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