GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats-Reference-Cited by-同舟云学术

GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

Published:2021-01-19 Issue:1 Volume:4 Page:296-313
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

van der Velden Wijnand J. C.¹^ORCID,Smit Florent X.¹,Christiansen Charlotte B.²³,Møller Thor C.⁴,Hjortø Gertrud M.¹,Larsen Olav¹^ORCID,Schiellerup Sine P.¹,Bräuner-Osborne Hans⁴^ORCID,Holst Jens J.²³,Hartmann Bolette²³,Frimurer Thomas M.⁵,Rosenkilde Mette M.¹^ORCID

Affiliation:

1. Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark

2. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark

3. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences University of Copenhagen, Copenhagen 2200, Denmark

4. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark

5. Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark

Funder

Novo Nordisk Fonden

Horizon 2020 Framework Programme

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.0c00193

Reference88 articles.

1. The Incretin Approach for Diabetes Treatment

2. Biology of Incretins: GLP-1 and GIP

3. G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus

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