Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System-Reference-Cited by-同舟云学术

Validating the Arrhythmogenic Potential of High-, Intermediate-, and Low-Risk Drugs in a Human-Induced Pluripotent Stem Cell-Derived Cardiac Microphysiological System

Published:2022-07-29 Issue:8 Volume:5 Page:652-667
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Charwat Verena¹^ORCID,Charrez Bérénice¹,Siemons Brian A.¹,Finsberg Henrik²^ORCID,Jæger Karoline H.²^ORCID,Edwards Andrew G.²,Huebsch Nathaniel¹^ORCID,Wall Samuel²^ORCID,Miller Evan³^ORCID,Tveito Aslak²,Healy Kevin E.¹⁴^ORCID

Affiliation:

1. Department of Bioengineering and California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, California 94720, United States

2. Simula Research Laboratory, 0164 Oslo, Norway

3. Department of Chemistry, University of California at Berkeley, Berkeley, California 94720, United States

4. Department of Materials Science and Engineering, University of California at Berkeley, Berkeley, California 94720, United States

Funder

Norges Forskningsr?d

National Heart, Lung, and Blood Institute

California Institute for Regenerative Medicine

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00088

Reference71 articles.

1. Drug Withdrawal Due to Safety: A Review of the Data Supporting Withdrawal Decision

2. Dealing with Global Safety Issues

3. Drug-induced QT prolongation and proarrhythmia: an inevitable link?

4. QT Prolongation and Malignant Arrhythmia: How Serious a Problem?

5. QT prolongation is an unreliable predictor of ventricular arrhythmia

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