Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth In Vivo

Author:

Comert Onder Ferah123,Kahraman Nermin1,Bellur Atici Esen4,Cagir Ali5,Kandemir Hakan6,Tatar Gizem7,Taskin Tok Tugba78,Kara Goknur1,Karliga Bekir4,Durdagi Serdar9ORCID,Ay Mehmet3ORCID,Ozpolat Bulent110ORCID

Affiliation:

1. Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 422, Houston, Texas 77030, United States,

2. Department of Medical Biology, Çanakkale Onsekiz Mart University, Faculty of Medicine, 17020 Canakkale, Turkey

3. Department of Chemistry, Natural Products and Drug Research Laboratory, Faculty of Science and Arts, Çanakkale Onsekiz Mart University, 17020 Canakkale, Turkey

4. DEVA Holding A.S. Cerkezkoy, 59500 Tekirdag, Turkey

5. Izmir Institute of Technology, Department of Chemistry, Bioorganic and Medicinal Chemistry Laboratory, 35430 Urla, Turkey

6. Tekirdag Namik Kemal University, Department of Chemistry, 59030 Tekirdag, Turkey

7. Gaziantep University, Institute of Health Sciences, Department of Bioinformatics and Computational Biology, 27310 Gaziantep, Turkey

8. Gaziantep University, Faculty of Arts and Sciences, Department of Chemistry, 27310 Gaziantep, Turkey

9. Department of Biophysics, School of Medicine, Computational Biology and Molecular Simulations Laboratory, Bahcesehir University, 34734 Istanbul, Turkey

10. Center for RNA Interference and Non-Coding RNAs, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, United States

Funder

National Cancer Institute

T?rkiye Bilimsel ve Teknolojik Arastirma Kurumu

University of Texas MD Anderson Cancer Center

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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