Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

Author:

Fields Francisco R.123ORCID,Manzo Giorgia4,Hind Charlotte K.5,Janardhanan Jeshina6,Foik Ilona P.7,Carmo Silva Phoebe Do5,Balsara Rashna D.68,Clifford Melanie5,Vu Henry M.18,Ross Jessica N.12,Kalwajtys Veronica R.1,Gonzalez Alejandro J.1,Bui Tam T.9,Ploplis Victoria A.68,Castellino Francis J.68,Siryaporn Albert710,Chang Mayland36ORCID,Sutton J. Mark5,Mason A. James4ORCID,Lee Shaun123ORCID

Affiliation:

1. Department of Biology, University of Notre Dame, Notre Dame, Indiana 46556, United States

2. Eck Institute of Global Health, University of Notre Dame, Notre Dame, Indiana 46556, United States

3. Chemistry Biology Biochemistry Interface, University of Notre Dame, Notre Dame, Indiana 46556, United States

4. Institue of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom

5. Technology Development Group, National Infection Service, Public Health England, Salisbury SP4 0JG, U.K.

6. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States

7. Department of Physics and Astronomy, University of California Irvine, Irvine, California 92697, United States

8. W.M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana 46556, United States

9. Centre for Biomolecular Spectroscopy and Randall Division of Cell and Molecular Biophysics, King’s College London, New Hunt’s House, London SE1 1UL, United Kingdom

10. Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California 92697, United States

Funder

National Institute of Allergy and Infectious Diseases

Office of the Director

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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