Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms

Author:

Apfel Verena1,Begue Damien2,Cordo’ Valentina1,Holzer Laura1,Martinuzzi Laetitia1,Buhles Alexandra1,Kerr Grainne1,Barbosa Ines1,Naumann Ulrike2,Piquet Michelle3,Ruddy David3,Weiss Andreas1,Ferretti Stephane1,Almeida Reinaldo4,Bonenfant Debora2,Tordella Luca1,Galli Giorgio G.1ORCID

Affiliation:

1. Disease area Oncology, Novartis Institute for Biomedical Research, Basel, Switzerland

2. Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland

3. Disease area Oncology, Novartis Institute for Biomedical Research, Cambridge, Massachusetts 02139United States

4. Global Discovery Chemistry, Novartis Institutes for Biomedical Research, CH-4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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