Cellular and Mitochondrial Toxicity of Tolcapone, Entacapone, and New Nitrocatechol Derivatives

Author:

Pinto Miguel123,Silva Tiago Barros123,Sardão Vilma A.45,Simões Rui46,Albuquerque Bárbara17,Oliveira Paulo J.46,Valente Maria João23,Remião Fernando23ORCID,Soares-da-Silva Patrício7ORCID,Fernandes Carlos1ORCID,Borges Fernanda1ORCID

Affiliation:

1. CIQUP-IMS − Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, R. Campo Alegre s/n, Porto 4169-007, Portugal

2. Associate Laboratory i4HB − Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, Porto 4050-313, Portugal

3. UCIBIO − Applied Molecular Biosciences Unit, REQUIMTE. Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, R. Jorge de Viterbo Ferreira 228, Porto 4050-313, Portugal

4. CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004−504, Portugal

5. MIA-Portugal - Multidisciplinary Institute of Aging, University of Coimbra, Coimbra 3004−504, Portugal

6. CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra 3004−504, Portugal

7. MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto 4200-319, Portugal

Funder

Fundação para a Ciência e a Tecnologia

Publisher

American Chemical Society (ACS)

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