Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation-Reference-Cited by-同舟云学术

Characterization of Dual-Acting A₃ Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gα_i3 and Gα_oA Isoprotein Activation

Published:2022-07-15 Issue:8 Volume:5 Page:625-641
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Fisher Courtney L.¹,Fallot Lucas B.²³⁴,Wan Tina C.¹,Keyes Robert F.⁵,Suresh R. Rama²^ORCID,Rothwell Amy C.¹,Gao Zhan-Guo²,McCorvy John D.⁶,Smith Brian C.⁵^ORCID,Jacobson Kenneth A.²^ORCID,Auchampach John A.¹^ORCID

Affiliation:

1. Department of Pharmacology & Toxicology and the Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States

2. Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States

3. Department of Biochemistry & Molecular Biology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, United States

4. Department of Chemistry & Life Science, United States Military Academy, 646 Swift Road, West Point, New York 10996, United States

5. Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States

6. Department of Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

American Heart Association

National Institute of General Medical Sciences

Medical College of Wisconsin Therapeutic Accelerator Program

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00076