Juglone as a Natural Quorum Sensing Inhibitor against Pseudomonas aeruginosa pqs-Mediated Virulence and Biofilms

Author:

Ma Yeping1,Tang Wing Suet1,Liu Sylvia Yang1,Khoo Bee Luan234,Chua Song Lin1567ORCID

Affiliation:

1. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR 999077, China

2. Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR 999077, China

3. Hong Kong Center for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong SAR 999077, China

4. City University of Hong Kong–Shenzhen Futian Research Institute, Shenzhen 518172, China

5. State Key Laboratory of Chemical Biology and Drug Discovery, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR 999077, China

6. Research Centre of Deep Space Explorations (RCDSE), The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR 999077, China

7. Research Institute for Future Food (RiFood), The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR 999077, China

Funder

Health and Medical Research Fund

Hong Kong Polytechnic University

State Key Laboratory of Chemical Biology and Drug Discovery Fund

Pneumoconiosis Compensation Fund Board

Environmental and Conservation Fund

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Reference57 articles.

1. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

2. aWHO Publishes List of Bacteria for Which New Antibiotics are Urgently Needed, 2019.

3. bAntibiotic Resistance Threats in the United States, 2019. https://www.cdc.gov/drugresistance/biggest-threats.html.

4. The role of bacterial biofilms in chronic infections

5. Biofilm matrix cloaks bacterial quorum sensing chemoattractants from predator detection

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