Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21-Reference-Cited by-同舟云学术

Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21

Published:2020-08-26 Issue:5 Volume:3 Page:978-986
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Pan Jia¹²,Parlee Sebastian D.¹,Brunel Florence M.¹^ORCID,Li Pengyun¹,Lu Wei¹,Perez-Tilve Diego³,Liu Fa⁴^ORCID,Finan Brian¹,Kharitonenkov Alexei¹⁵,DiMarchi Richard D.¹⁶^ORCID

Affiliation:

1. Novo Nordisk Research Center − Indianapolis, Inc., Indianapolis, Indiana 46241, United States

2. Novo Nordisk Research Centre China, Novo Nordisk A/S, Beijing 102206, China

3. University of Cincinnati, Cincinnati, Ohio 45221, United States

4. Novo Nordisk Research Center Seattle, Seattle, Washington 98109, United States

5. AK Biotechnologies LLC, Zionsville, Indiana 46077, United States

6. Indiana University, Bloomington, Indiana 47405, United States

Funder

Novo Nordisk

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.0c00100

Reference38 articles.

1. The FGF family: biology, pathophysiology and therapy

2. Circulating Fibroblast Growth Factors as Metabolic Regulators—A Critical Appraisal

3. Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy

4. Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism

5. FGF21 Requires βklotho to Act In Vivo

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