Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins

Author:

Liang Yi-Lynn1,Belousoff Matthew J.1,Fletcher Madeleine M.1,Zhang Xin1,Khoshouei Maryam2,Deganutti Giuseppe3ORCID,Koole Cassandra1,Furness Sebastian G. B.1ORCID,Miller Laurence J.14,Hay Debbie L.5ORCID,Christopoulos Arthur1,Reynolds Christopher A.3,Danev Radostin6ORCID,Wootten Denise17,Sexton Patrick M.17ORCID

Affiliation:

1. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia

2. Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany

3. School of Biological Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom

4. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona 85259, United States

5. School of Biological Sciences, and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1142, New Zealand

6. Graduate School of Medicine, University of Tokyo, S402, 7-3-1 Hongo, Bunkyo-ku, 113-0033 Tokyo, Japan

7. School of Pharmacy, Fudan University, Shanghai 201203, China

Funder

Royal Society

National Health and Medical Research Council

Precursory Research for Embryonic Science and Technology

Australian Research Council

Japan Society for the Promotion of Science

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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