Electrophysiological and Proarrhythmic Effects of Hydroxychloroquine Challenge in Guinea-Pig Hearts

Author:

Wang Gongxin1,Lu Chieh-Ju1,Trafford Andrew W.2,Tian Xiaohui3,Flores Hannali M4,Maj Piotr5,Zhang Kevin6,Niu Yanhong7,Wang Luxi1,Du Yimei8,Ji Xinying3,Xu Yanfang9,Wu Lin10,Li Dan11,Herring Neil11,Paterson David11,Huang Christopher L.-H.1213ORCID,Zhang Henggui41413,Lei Ming513,Hao Guoliang111

Affiliation:

1. Henan SCOPE Research Institute of Electrophysiology Co. Ltd., Kaifeng 475000, China

2. Unit of Cardiac Physiology, Institute of Cardiovascular Sciences, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester M13 9PL, U.K.

3. Department of Pharmacy, Huaihe Hospital and College of Medicine, Henan University, Kaifeng 475000, China

4. Biological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester M13 9PL, U.K.

5. Department of Pharmacology, University of Oxford, Oxford OX1 2JD, U.K.

6. School of Medicine, Imperial College of London, London SW7 2AZ, U.K.

7. Fuwai Central China Cardiovascular Hospital, Zhengzhou 450003, China

8. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

9. Department of Pharmacology, Hebei Medical University, Shijiazhuang City 050017, China

10. Department of Cardiology, Peking University First Hospital, Beijing 100034, China

11. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 2JD, U.K.

12. Physiological Laboratory and Department of Biochemistry, University of Cambridge, Cambridge CB2 3EG, U.K.

13. Key Laboratory of Medical Electrophysiology of the Ministry of Education and Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China

14. Peng Cheng Laboratory, Shenzhen 518066, China

Funder

Engineering and Physical Sciences Research Council

British Heart Foundation

National Natural Science Foundation of China

Kaifeng Excellent Key Laboratory Grant

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

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