Perspective: Implications of Ligand–Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors-Reference-Cited by-同舟云学术

Perspective: Implications of Ligand–Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors

Published:2020-03-18 Issue:2 Volume:3 Page:179-189
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

van der Velden Wijnand J. C.¹,Heitman Laura H.²,Rosenkilde Mette M.¹^ORCID

Affiliation:

1. Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK 2200, Denmark

2. Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden 2333 CC, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.0c00012

Reference109 articles.

1. The Role of Target Binding Kinetics in Drug Discovery

2. Drug–Target Kinetics in Drug Discovery

3. Biochemical mechanisms of drug action: what does it take for success?

4. Drug–target residence time and its implications for lead optimization

5. Calculating receptor number from binding experiments using same compound as radioligand and competitor

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