Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs-Reference-Cited by-同舟云学术

Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and Their Prodrugs

Published:2023-02-20 Issue:3 Volume:6 Page:422-446
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Park Jung-Eun¹,Lee Hobin¹²,Oliva Paola²,Kirsch Klara¹,Kim Bora¹,Ahn Jong Il¹,Alverez Celeste N.¹³,Gaikwad Snehal⁴,Krausz Kristopher W.¹,O’Connor Robert²,Rai Ganesha³^ORCID,Simeonov Anton³,Mock Beverly A.⁴,Gonzalez Frank J.¹,Lee Kyung S.¹^ORCID,Jacobson Kenneth A.²^ORCID

Affiliation:

1. Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States

2. Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States

3. Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States

4. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States

Funder

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00250

Reference61 articles.

1. Targeting polo-like kinase 1 for cancer therapy

2. Current assessment of polo-like kinases as anti-tumor drug targets

3. Thoughts on the current assessment of Polo-like kinase inhibitor drug discovery

4. Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy

5. BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Synthetic Approach to Synthesize Furan‐2‐Carboxylate Derivatives by Using a Magnetic Sodium Aluminate Catalyst;ChemistrySelect;2024-05-06

2. Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition;Proceedings of the National Academy of Sciences;2023-08-21