Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation-Reference-Cited by-同舟云学术

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Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation

Published:2022-09-05 Issue:10 Volume:5 Page:849-858
ISSN:2575-9108
Container-title:ACS Pharmacology & Translational Science
language:en
Short-container-title:ACS Pharmacol. Transl. Sci.

Author:

Ruffilli Camilla¹²,Roth Sascha¹^ORCID,Rodrigo Monica¹,Boyd Helen³,Zelcer Noam²^ORCID,Moreau Kevin¹^ORCID

Affiliation:

1. Safety Innovation and PROTAC Safety, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge CB2 0SL, United Kingdom

2. Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Amsterdam 1000 GG, The Netherlands

3. Precision Medicine & Biosamples, R&D, AstraZeneca, Cambridge CB2 0SL, United Kingdom

Funder

Vici grant from the Netherlands Organization for Scientific Research

European Union?s Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie Grant Agreement

Publisher

American Chemical Society (ACS)

Subject

Pharmacology (medical),Pharmacology

Link

https://pubs.acs.org/doi/pdf/10.1021/acsptsci.2c00142

Reference77 articles.

1. Sequential liquid biopsies reveal dynamic alterations of EGFR driver mutations and indicate EGFR amplification as a new mechanism of resistance to osimertinib in NSCLC

2. Novel ALK inhibitors in clinical use and development

3. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

4. Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer

5. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

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