1. Department of Research, BIAL - Portela & Ca, S.A., Coronado (S. Mamede e S. Romão) 4747-457, Portugal
2. Department of Biomedicine, Unit of Pharmacology & Therapeutics, Faculty of Medicine, University of Porto, Porto 4200-319, Portugal
3. MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto 4200-319, Portugal