HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants-Reference-Cited by-同舟云学术

HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

Published:2008-04-16 Issue:19 Volume:130 Page:6099-6113
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Altman Michael D.¹,Ali Akbar¹,Kumar Reddy G. S. Kiran¹,Nalam Madhavi N. L.¹,Anjum Saima Ghafoor¹,Cao Hong¹,Chellappan Sripriya¹,Kairys Visvaldas¹,Fernandes Miguel X.¹,Gilson Michael K.¹,Schiffer Celia A.¹,Rana Tariq M.¹,Tidor Bruce¹

Affiliation:

1. Department of Chemistry, Department of Biological Engineering, and Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Biochemistry and Molecular Pharmacology, and Chemical Biology Program, University of Massachuetts Medical School, Worcester, Massachusetts 01605, and Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, Maryland 20850

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja076558p

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1. Multiple-Drug Resistance in Human Cancer

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5. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.

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