Stereoselective Epoxidation and Hydration at the K-Region of Polycyclic Aromatic Hydrocarbons by cDNA-expressed Cytochromes P450 1A1, 1A2, and Epoxide Hydrolase
Author:
Affiliation:
1. Laboratory of Molecular Carcinogenesis, National Cancer Institute, Building 37, Room 3E24, National Institutes of Health, Bethesda, Maryland 20892
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi962042z
Reference44 articles.
1. Expression of P1-450 and P3-450 DNA coding sequences as enzymatically active cytochromes P-450 in mammalian cells.
2. Oxidation of Benzo[a]pyrene by Recombinant Human Cytochrome P450 Enzymes
3. Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
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