Modulating the Therapeutic Activity of Nanoparticle Delivered Paclitaxel by Manipulating the Hydrophobicity of Prodrug Conjugates-Reference-Cited by-同舟云学术

Modulating the Therapeutic Activity of Nanoparticle Delivered Paclitaxel by Manipulating the Hydrophobicity of Prodrug Conjugates

Published:2008-05-09 Issue:11 Volume:51 Page:3288-3296
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ansell Steven M.¹,Johnstone Sharon A.¹,Tardi Paul G.¹,Lo Lily¹,Xie Sherwin¹,Shu Yu¹,Harasym Troy O.¹,Harasym Natashia L.¹,Williams Laura¹,Bermudes David¹,Liboiron Barry D.¹,Saad Walid¹,Prud’homme Robert K.¹,Mayer Lawrence D.¹

Affiliation:

1. Celator Pharmaceuticals Corporation, 1779 West 75th Avenue, Vancouver, B.C., V6P 6P2, Canada, and Department of Chemical Engineering, Princeton University, Princeton, New Jersey

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800002y

Reference31 articles.

1. Increased Preclinical Efficacy of Irinotecan and Floxuridine Coencapsulated Inside Liposomes Is Associated With Tumor Delivery of Synergistic Drug Ratios

2. Optimizing Combination Chemotherapy by Controlling Drug Ratios

3. Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice

4. Transfer of lipophilic drugs between liposomal membranes and biological interfaces: Consequences for drug delivery

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