High-Efficiency Biocatalytic Conversion of Thebaine to Codeine

Author:

Li Xu12ORCID,Krysiak-Baltyn Konrad12,Richards Luke12ORCID,Jarrold Ailsa3ORCID,Stevens Geoffrey W.1ORCID,Bowser Tim4,Speight Robert E.5ORCID,Gras Sally L.12ORCID

Affiliation:

1. Department of Chemical Engineering, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia

2. The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia

3. Sun Pharmaceutical Industries Australia Pty Ltd., Princes Highway, Port Fairy, Victoria 3281, Australia

4. Impact Science Consulting, Unit 2/52 Swanston Street, Heidelberg Heights, Melbourne, Victoria 3081, Australia

5. School of Biology and Environmental Science, Queensland University of Technology, Brisbane, Queensland 4000, Australia

Funder

Australian Research Council

Sun Pharmaceutical Industries (Australia) Pty Ltd

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Reference38 articles.

1. Symons, G. M.; Hudson, C. J.; Livermore, M. L. Papaver somniferum with high concentration of codeine. WO 2009143574 A1, 2009.

2. Winzer, T.; Walker, T. C.; MEADE, F.; Larson, T. R.; Graham, I.A. Modified Plant. WO 2017122011 A1, 2017.

3. Department of Justice, US Drug Enforcement Administration. https://www.dea.gov/press-releases/2018/08/16/justice-department-dea-propose-significant-opioid-manufacturing-reduction (accessed 2020-01-10).

4. Fist, A. J. The Tasmanian Poppy Industry: A Case Study of the Application of Science and Technology. Proceedings of the Australian Agronomy Conference 2001.

5. WHO Model List of Essential Medicines, 21st List; World Health Organization, 2019 (https://www.who.int/medicines/publications/essentialmedicines/en/).

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