Optimized Fmoc-Removal Strategy to Suppress the Traceless and Conventional Diketopiperazine Formation in Solid-Phase Peptide Synthesis
Author:
Affiliation:
1. Chemical Development, Global Pharmaceutical R&D, Ferring Pharmaceuticals A/S, Amager Strandvej 405, DK-2770 Kastrup, Denmark
Publisher
American Chemical Society (ACS)
Subject
General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c00214
Reference16 articles.
1. Yang, Y. Side Reactions in Peptide Synthesis; Academic Press, 2015; pp 22–28.
2. Cis–trans isomerization of omega dihedrals in proteins
3. Cis–trans peptide variations in structurally similar proteins
4. cis–trans-Amide isomerism of the 3,4-dehydroproline residue, the ‘unpuckered’ proline
5. Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids
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