Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-<i>a</i>]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A-Reference-Cited by-同舟云学术

Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A

Published:2023-10-10 Issue:42 Volume:8 Page:39546-39561
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Yang Xuan¹²,Ong Han Wee¹²^ORCID,Dickmander Rebekah J.²³⁴⁵,Smith Jeffery L.¹,Brown Jason W.⁶,Tao William⁶,Chang Edcon⁶^ORCID,Moorman Nathaniel J.²³⁴,Axtman Alison D.¹²^ORCID,Willson Timothy M.¹²^ORCID

Affiliation:

1. Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

2. Rapidly Emerging Antiviral Drug Development Initiative (READDI), Chapel Hill, North Carolina 27599, United States

3. Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

4. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

5. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

6. Takeda Development Center Americas, Inc., San Diego, California 92121, United States

Funder

University of North Carolina at Chapel Hill

U.S. Department of Defense

Common Fund

NC Biotech Center

Millennium Pharmaceuticals

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c05377

Reference34 articles.

1. Therapeutic strategies for COVID-19: progress and lessons learned

2. Host-Directed Antiviral Therapy

3. Kinase Inhibitors as Underexplored Antiviral Agents

4. Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection

5. Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses

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