Discovery of a Hidden <i>Trypanosoma cruzi</i> Spermidine Synthase Binding Site and Inhibitors through <i>In Silico, In Vitro</i>, and X-ray Crystallography-Reference-Cited by-同舟云学术

Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography

Published:2023-07-12 Issue:29 Volume:8 Page:25850-25860
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Yoshino Ryunosuke¹²,Yasuo Nobuaki³^ORCID,Hagiwara Yohsuke²⁴,Ishida Takashi⁵^ORCID,Inaoka Daniel Ken⁶⁷,Amano Yasushi⁴,Tateishi Yukihiro⁴,Ohno Kazuki²⁴,Namatame Ichiji⁴,Niimi Tatsuya⁴,Orita Masaya⁴,Kita Kiyoshi⁶⁷,Akiyama Yutaka²⁵^ORCID,Sekijima Masakazu²⁵^ORCID

Affiliation:

1. Transborder Medical Research Center, University of Tsukuba, Tsukuba 305-8577, Japan

2. Education Academy of Computational Life Sciences (ACLS), Tokyo Institute of Technology, Yokohama 226-8501, Japan

3. Tokyo Tech Academy for Convergence of Materials and Informatics (TAC-MI), Tokyo Institute of Technology, Meguro, Tokyo 152-8550, Japan

4. Medicinal Chemistry Research Labs, Drug Discovery Research, Astellas Pharma Inc, Miyukigaoka, Tsukuba 305-8585, Japan

5. School of Computing, Tokyo Institute of Technology, Tokyo 152-8550, Japan

6. School of Tropical Medicine and Global Health, Nagasaki University, Sakamoto, Nagasaki 852-8523, Japan

7. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c01314

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