Imidazo[1,2-a]pyrimidine as a New Antileishmanial Pharmacophore against Leishmania amazonensis Promastigotes and Amastigotes

Author:

Kumar Ravinder1,Singh Rahul1,das Chagas Almeida Ayla2,da Trindade Granato Juliana2,de Oliveira Lemos Ari Sérgio2,Kumar Kushvinder1,Patil Madhuri T.3,da Silva Adilson D.4,Rode Ambadas B.5ORCID,Coimbra Elaine S.2,Salunke Deepak B.16ORCID

Affiliation:

1. Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160 014, India

2. Department of Parasitology, Microbiology and Immunology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil

3. Mehr Chand Mahajan DAV College for Women, Sector 36, Chandigarh 160036, India

4. Department of Chemistry, Institute of Exacts Sciences, Federal University of Juiz de Fora, 36036-900, Juiz de Fora, Brazil

5. Regional Centre for Biotechnology, NCR Biotech Science Cluster, third Milestone, Faridabad-Gurgaon Expressway, Faridabad - 121 001, India

6. National Interdisciplinary Centre of Vaccine, Immunotherapeutic and Antimicrobials, Panjab University, Chandigarh 160 014, India

Funder

Indian Council of Medical Research

Science and Engineering Research Board

Department of Biotechnology, Ministry of Science and Technology, India

Department of Science and Technology, Ministry of Science and Technology, India

Universidade Federal de Juiz de Fora

Chandigarh Administration

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Reference36 articles.

1. WHO 2023. Epidemiological situation. http://www.who.int/leishmaniasis/burden/en/ (accessed May 2023).

2. Ruiz-Postigo, J. A.; Grouta, L.; Saurabh, J. 2020. Global leishmaniasis surveillance, 2017–2018, and first report on 5 additional indicators. https://www.who.int/publications-detail-redirect/who-wer9525 (accessed May 2023).

3. American tegumentary leishmaniasis in Brazil: a critical review of the current therapeutic approach with systemic meglumine antimoniate and short‐term possibilities for an alternative treatment

4. Current and emerging medications for the treatment of leishmaniasis

5. Treatment of Leishmaniasis: A Review and Assessment of Recent Research

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