Chromatographic Analysis of the <i>N</i>-Glycan Profile on Therapeutic Antibodies Using FcγRIIIa Affinity Column Chromatography-Reference-Cited by-同舟云学术

Chromatographic Analysis of the N-Glycan Profile on Therapeutic Antibodies Using FcγRIIIa Affinity Column Chromatography

Published:2023-04-28 Issue:18 Volume:8 Page:16513-16518
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Hiranyakorn Methanee¹,Iwamoto Shogo²,Hoshinoo Asako²,Tsumura Ryo³,Takashima Hiroki³^ORCID,Yasunaga Masahiro³^ORCID,Manabe Shino¹⁴⁵^ORCID

Affiliation:

1. Laboratory of Functional Molecule Chemistry, Pharmaceutical Department, Hoshi University, Ebara, Shinagawa, Tokyo 142-8501, Japan

2. Fushimi Pharmaceutical Co. Ltd., Nakatsu, Marugame, Kagawa 763-8605 Japan

3. Division of Developmental Therapeutics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa City 277-8577, Japan

4. Institute of Medicinal Chemistry, Hoshi University, Ebara, Shinagawa, Tokyo 142-8501, Japan

5. Research Center for Pharmaceutical Development Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan

Funder

Adaptable and Seamless Technology Transfer Program through Target-Driven R and D

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c02374

Reference24 articles.

1. The Impact of Glycosylation on the Biological Function and Structure of Human Immunoglobulins

2. Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity

3. The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity

4. Effects of N-Glycan Composition on Structure and Dynamics of IgG1 Fc and Their Implications for Antibody Engineering

5. Dynamic Views of the Fc Region of Immunoglobulin G Provided by Experimental and Computational Observations