Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein–Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1–C9 Macrolactone Part and the C24

Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein–Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1–C9 Macrolactone Part and the C24–C34 Side Chain

Published:2019-05-16 Issue:5 Volume:4 Page:8598-8613
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Futaki Kentaro¹,Takahashi Momoko¹,Tanabe Kenta¹,Fujieda Akari²,Kigoshi Hideo¹^ORCID,Kita Masaki¹²^ORCID

Affiliation:

1. Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8571, Japan

2. Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8601, Japan

Funder

Naito Foundation

Program on Open Innovation Platform with Enterprises, Research Institute and Academia

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsomega.9b01099

Reference59 articles.

1. Bovens, S.; Ottmann, C. In Chemical Biology: Learning through Case Studies; Waldmann, H., Jannig, P., Eds. Wiley-VCH Verlag GmbH: Weinheim, 2009; pp 105–119.

2. Marine natural products that interfere with multiple cytoskeletal protein interactions

3. Aplyronine A, a potent antitumor substance and the congeners aplyronines B and C isolated from the sea hare Aplysia kurodai

4. Further studies on aplyronine A, an antitumor substance isolated from the sea hare Aplysia kurodai

5. Studies on the stereochemistry of aplyronine A: Determination of the stereochemistry of the C21C34 fragment

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