Finding Lead Compounds for Dengue Antivirals from a Collection of Old Drugs through In Silico Target Prediction and Subsequent In Vitro Validation

Author:

Abdullah Zafirah Liyana1,Chee Hui-Yee2,Yusof Rohana3,Mohd Fauzi Fazlin45ORCID

Affiliation:

1. Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia

2. Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

3. Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

4. Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, UiTM Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia

5. Collaborative Drug Discovery Research, Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia

Funder

Kementerian Pendidikan Malaysia

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Reference57 articles.

1. World Health Organization. Dengue and Severe Dengue, 2018. http://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue. (accessed October 26, 2018).

2. Dengue Worldwide Overview, 2022. https://www.ecdc.europa.eu/en/dengue-monthly. (accessed July 06, 2022).

3. Current Trends and Limitations in Dengue Antiviral Research

4. First FDA-approved vaccine for the prevention of dengue disease in endemic regions [Press release] U.S. Food and Drug Administration.https://www.fda.gov/news-events/press-announcements/first-fda-approved-vaccine-prevention-dengue-disease-endemic-regions (accessed July 27, 2023).

5. Current Status of Dengue Therapeutics Research and Development

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