Binding Selectivity of Inhibitors toward Bromodomains BAZ2A and BAZ2B Uncovered by Multiple Short Molecular Dynamics Simulations and MM-GBSA Calculations-Reference-Cited by-同舟云学术

Binding Selectivity of Inhibitors toward Bromodomains BAZ2A and BAZ2B Uncovered by Multiple Short Molecular Dynamics Simulations and MM-GBSA Calculations

Published:2021-04-28 Issue:18 Volume:6 Page:12036-12049
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Wang Lifei¹^ORCID,Wang Yan¹,Yang Zhiyong²,Xu Shuobo³,Li Hongyun¹

Affiliation:

1. School of Science, Shandong Jiaotong University, 5001 Haitang Road, Changqing District, Jinan, Shandong Province 250357, China

2. Department of Physics, Jiangxi Agricultural University, 1101 Zhimin Road, Economic and Technological Development Zone, Nanchang, Jiangxi Province 330045, China

3. School of Information Science and Electrical Engineering, Shandong Jiaotong University, 5001 Haitang Road, Changqing District, Jinan, Shandong Province 250357, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.1c00687

Reference106 articles.

1. The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p

2. Binding Mode of Acetylated Histones to Bromodomains: Variations on a Common Motif

3. Bromodomains as therapeutic targets

4. Bromodomains as therapeutic targets in cancer

5. BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

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