Attenuation of Lipopolysaccharide-Induced Inflammatory Responses through Inhibition of the NF-κB Pathway and the Increased NRF2 Level by a Flavonol-Enriched n-Butanol Fraction from Uvaria alba

Author:

Notarte Kin Israel R.12ORCID,Quimque Mark Tristan J.13ORCID,Macaranas Imee T.4,Khan Abbas5ORCID,Pastrana Adriel M.4,Villaflores Oliver B.6ORCID,Arturo Hans Christian P.1,Pilapil IV Delfin Yñigo H.1ORCID,Tan Sophia Morgan M.1,Wei Dong-Qing5ORCID,Wenzel-Storjohann Arlette7,Tasdemir Deniz78ORCID,Yen Chia-Hung9ORCID,Ji Seon Yeong10,Kim Gi-Young11ORCID,Choi Yung Hyun10,Macabeo Allan Patrick G.1ORCID

Affiliation:

1. Laboratory of Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for Natural and Applied Sciences, University of Santo Tomas, España, 1015Manila, Philippines

2. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland21218, United States

3. Chemistry Department, College of Science and Mathematics, Mindanao State University - Iligan Institute of Technology, Tibanga, 9200Iligan City, Philippines

4. Faculty of Medicine and Surgery, University of Santo Tomas, España, 1008Manila, Philippines

5. Department of Bioinformatics and Biostatistics, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, 800 Dongchuan Road Shanghai, Minhang District, Shanghai200240, China

6. Laboratory of Phytochemistry, Research Center for Natural and Applied Sciences, University of Santo Tomas, España, 1015Manila, Philippines

7. GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Product Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, 24106Kiel, Germany

8. Faculty of Mathematics and Natural Sciences, Kiel University, 24118Kiel, Germany

9. National Natural Product Libraries and High-Throughput Screening Core Facility, Kaohsiung Medical University, Kaohsiung80708, Taiwan

10. Department of Biochemistry, Dongeui University College of Korean Medicine, 52-57, Yangjeong-ro, Busanjin-gu, Busan47227Republic of Korea

11. Department of Marine Life Science, Jeju National University, 102 Jejudaehak-ro, Jeju-si, Jeju Special Self-Governing Province63243, Republic of Korea

Funder

International Foundation for Science

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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