Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRAS<sup>G12D</sup> Mutation-Reference-Cited by-同舟云学术

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Discovery of Prodrug of MRTX1133 as an Oral Therapy for Cancers with KRAS^G12D Mutation

Published:2023-02-09 Issue:7 Volume:8 Page:7211-7221
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Ji Xiang¹²^ORCID,Li Yan²,Kong Xianqi²,Chen Dawei²,Lu Jiasheng²³

Affiliation:

1. Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200437, China

2. Risen (Shanghai) Pharma Tech Co., Ltd., Shanghai 201210, China

3. Guangdong Key Laboratory of Nanomedicine, Chinese Academy of Sciences, Shenzhen 518055, China

Funder

Risen (Shanghai) Pharmaceutical Technology Co. Ltd.

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c00329

Reference34 articles.

2. Human RAS Superfamily Proteins and Related GTPases

3. AACR Project GENIE: Powering Precision Medicine through an International Consortium

4. KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

5. A Comprehensive Survey of Ras Mutations in Cancer

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Inhibition of GTPase KRAS ^G12D : a review of patent literature;Expert Opinion on Therapeutic Patents;2024-06-26

2. Targeting RAF dimers in RAS mutant tumors: From biology to clinic;Acta Pharmaceutica Sinica B;2024-05

3. Activity of the KRAS G12D Inhibitor MRTX1133 against the Mutant KRAS Triple-Negative MDA-MB-231 Breast Cancer Cell Line;J BIOL REG HOMEOS AG;2024

4. Salvianolic acid F suppresses KRAS-dependent lung cancer cell growth through the PI3K/AKT signaling pathway;Phytomedicine;2023-12

5. A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer;Clinical Cancer Research;2023-11-09

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