New Pyrimidinone Bearing Aminomethylenes and Schiff Bases as Potent Antioxidant, Antibacterial, SARS-CoV-2, and COVID-19 Main Protease MPro Inhibitors: Design, Synthesis, Bioactivities, and Computational Studies

Author:

Sarfraz Muhammad1,Ayyaz Muhammad1,Rauf Abdul1,Yaqoob Asma2,Tooba 2,Arif Ali Muhammad1,Siddique Sabir Ali1,Qureshi Ashfaq Mahmood3,Sarfraz Muhammad Hassan4ORCID,Aljowaie Reem M.5,Almutairi Saeedah Musaed5,Arshad Muhammad1ORCID

Affiliation:

1. Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

2. Institute of Biochemistry, Biotechnology, and Bioinformatics. Department of Biochemistry and Molecular Biology, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan

3. Department of Chemistry, Government Sadiq College Women University, Bahawalpur 63100, Pakistan

4. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Institute of Musculoskeletal Sciences, University of Oxford, OxfordOX3 7LD, United Kingdom

5. Department of Botany and Microbiology, College of Science, King Saud University, P O 2455 Riyadh 11451, Saudi Arabia

Funder

King Saud University

Publisher

American Chemical Society (ACS)

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