Induction of Caspase-Mediated Apoptosis in HepG2 Liver Carcinoma Cells Using Mutagen–Antioxidant Conjugated Self-Assembled Novel Carbazole Nanoparticles and In Silico Modeling Studies

Author:

Anand Krishnan1,Abdul Naeem Sheik2,Ghazi Terisha2,Ramesh Muthusamy3,Gupta Gaurav4,Tambuwala Murtaza M.56ORCID,Dureja Harish7,Singh Sachin Kumar8,Chellappan Dinesh Kumar9,Dua Kamal101112,Pandi Boomi13,Saravanan Muthupandian14ORCID,Chuturgoon Anil Amichund2ORCID

Affiliation:

1. Department of Chemical Pathology, School of Pathology, Faculty of Health Sciences and National Health Laboratory Service, University of the Free State, Bloemfontein 9300, South Africa

2. Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban 4041, South Africa

3. Department of Pharmaceutical Analysis, Omega College of Pharmacy, Hyderabad 501 301, India

4. School of Pharmacy, Suresh Gyan Vihar University, Jagatpura Mahal Road, Jaipur 302017, India

5. School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, County Londonderry, Northern Ireland BT52 1SA, United Kingdom

6. School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland BT52 1SA, United Kingdom

7. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001 Haryana, India

8. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India

9. School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia

10. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, New South Wales 2007, Australia

11. Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) & School of Biomedical Sciences and Pharmacy, The University of Newcastle (UoN), Callaghan, New South Wales 2308, Australia

12. School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India

13. Department of Bioinformatics, Alagappa University, Karaikudi 630 003, India

14. Department of Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine, College of Health Sciences, Mekelle University, Mekelle 1871, Ethiopia

Funder

Inyuvesi Yakwazulu-Natali

National Research Foundation

Universiteit van die Vrystaat

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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