Biotransformation, Using Recombinant CYP450-Expressing Baker’s Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme-Reference-Cited by-同舟云学术

Biotransformation, Using Recombinant CYP450-Expressing Baker’s Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme

Published:2018-08-09 Issue:8 Volume:3 Page:8903-8912
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Williams Ibidapo S.¹,Gatchie Linda¹,Bharate Sandip B.²^ORCID,Chaudhuri Bhabatosh¹^ORCID

Affiliation:

1. CYP Design Ltd, The Innovation Centre, 49 Oxford Street, Leicester LE1 5XY, U.K.

2. Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsomega.8b00809

Reference57 articles.

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2. Opioid Metabolism and Effects of Cytochrome P450

3. Comparative Metabolic Capabilities and Inhibitory Profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17

4. Stable expression of human cytochrome P450 2D6*10 in HepG2 cells

5. Human cytochrome P450 (CYP) genes: recommendations for the nomenclature of alleles

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