Intermolecular Interactions of Nucleoside Antibiotic Tunicamycin with On-Target MraY<sub>CB</sub>-TUN and Off-Target DPAGT1-TUN in the Active Sites Delineated by Quantum Mechanics/Molecular Mechanics Calculations-Reference-Cited by-同舟云学术

Intermolecular Interactions of Nucleoside Antibiotic Tunicamycin with On-Target MraY_CB-TUN and Off-Target DPAGT1-TUN in the Active Sites Delineated by Quantum Mechanics/Molecular Mechanics Calculations

Published:2022-09-06 Issue:37 Volume:7 Page:32970-32987
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Astani Elahe K.¹²,Malek Zadeh Saeid³⁴⁵,Hsu Ning-Shian³,Lin Kuan-Hung³,Sardari Soroush¹,Li Tsung-Lin³⁴⁶⁷^ORCID

Affiliation:

1. Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran 13169-43551, Iran

2. Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran 14115-175, Iran

3. Genomics Research Center, Academia Sinica, Taipei 11529, Taiwan

4. Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan

5. Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 30013, Taiwan

6. Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan

7. Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan

Funder

Academia Sinica

Ministry of Science and Technology, Taiwan

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c02213

Reference85 articles.

1. Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

2. GlcNAc-1-P-transferase–tunicamycin complex structure reveals basis for inhibition of N-glycosylation

3. Effect of N-linked glycosylation on glycopeptide and glycoprotein structure

4. Metabolic Mimics: The Disorders of N-Linked Glycosylation

5. Solubilization and properties of mannose and N-acetylglucosamine transferases involved in formation of polyprenyl-sugar intermediates.

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