Unraveling the Molecular Landscape of SCN1A Gene Knockout in Cerebral Organoids: A Multiomics Approach Utilizing Proteomics, Lipidomics, and Transcriptomics

Author:

Koh Byumseok1ORCID,Kim Young Eun23,Park Sung Bum1,Kim Seong Soon1ORCID,Lee Jangjae45,Jo Jeong Hyeon16,Lee KyungJin78,Bae Dong Hyuck7,Kim Tae-Young3ORCID,Cho Sung-Hee4,Bae Myung Ae1,Kang Dukjin2,Kim Ki Young1

Affiliation:

1. Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Republic of Korea

2. Group for Biometrology, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea

3. School of Earth Sciences & Environmental Engineering, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea

4. Chemical Platform Technology Division, Korea Research Institute of Chemical Technology (KRICT), 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Republic of Korea

5. Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea

6. Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea

7. Department of Microbiology, CHA University School of Medicine, 335 Pangyo-ro, Seongnam 13488, Republic of Korea

8. ORGANOIDSCIENCES, 335 Pangyo-ro, Seongnam 13488, Republic of Korea

Funder

Korea Research Institute of Chemical Technology

Ministry of Science and ICT, South Korea

Ministry of Trade, Industry and Energy

Publisher

American Chemical Society (ACS)

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