Unveiling the Antiviral Capabilities of Targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2-Reference-Cited by-同舟云学术

Unveiling the Antiviral Capabilities of Targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2

Published:2024-02-28 Issue:10 Volume:9 Page:11418-11430
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Purificação Aline D.¹²^ORCID,Silva-Mendonça Sabrina²³,Cruz Luiza V.²³,Sacramento Carolina Q.⁴⁵,Temerozo Jairo R.⁴⁵⁶,Fintelman-Rodrigues Natalia⁴⁵,de Freitas Caroline Souza⁴⁵,Godoi Bruna Fleck²⁷,Vaidergorn Miguel Menezes²⁷,Leite Juliana Almeida⁸,Salazar Alvarez Luis Carlos⁸,Freitas Murillo V.³,Silvac Meryck F. B.³⁹^ORCID,Martin Bianca A.¹⁰,Lopez Renata F. V.¹⁰^ORCID,Neves Bruno J.⁹^ORCID,Costa Fabio T. M.⁸,Souza Thiago M. L.⁴⁵,da Silva Emery Flavio²⁷^ORCID,Andrade Carolina Horta²³¹¹^ORCID,Nonato M. Cristina¹²

Affiliation:

1. Protein Crystallography Laboratory, Department of Biomolecular Sciences, School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto 05508-060, SP, Brazil

2. Center for the Research and Advancement in Fragments and molecular Targets (CRAFT), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto 05508-060, SP, Brazil

3. Laboratory for Molecular Modeling and Drug Design (LabMol), Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia 74605-170, GO, Brazil

4. Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil

5. National Institute for Science and Technology on Innovation in Diseases of Neglected Populations (INCT/IDPN), Center for Technological Development in Health (CDTS), Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil

6. National Institute for Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil

7. Laboratory of Heterocyclic and Medicinal Chemistry (QHeteM), Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirao Preto 05508-060, SP, Brazil

8. Laboratory of Tropical Diseases, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, Unicamp, Campinas 13.083-857, SP, Brazil

9. Laboratory of Cheminformatics, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia 74605-170, GO, Brazil

10. Innovation Center in Nanostructured Systems and Topical Administration (NanoTop), School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto 05508-060, SP, Brazil

11. Center for Excellence in Artificial Intelligence (CEIA), Institute of Informatics, Universidade Federal de Goiás, Goiânia 74605-170, GO, Brazil

Funder

Funda??o de Amparo ? Pesquisa do Estado de Goi?s

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c07845

Reference85 articles.

1. Coronavirus Disease (COVID-19), 2019. https://www.who.int/emergencies/diseases/novel-coronavirus-2019.

2. Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape

3. COVID-19 vaccine development: milestones, lessons and prospects

4. Coronavirus pandemic (COVID-19). Our World in Data. https://ourworldindata.org/coronavirus.

5. Remdesivir and COVID-19

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