Dihydropyrazole Derivatives Act as Potent α-Amylase Inhibitors and Free Radical Scavengers: Synthesis, Bioactivity Evaluation, Structure–Activity Relationship, ADMET, and Molecular Docking Studies-Reference-Cited by-同舟云学术

Dihydropyrazole Derivatives Act as Potent α-Amylase Inhibitors and Free Radical Scavengers: Synthesis, Bioactivity Evaluation, Structure–Activity Relationship, ADMET, and Molecular Docking Studies

Published:2023-06-02 Issue:23 Volume:8 Page:20412-20422
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Ali Arif¹,Shah Muhammad Ishaq Ali¹^ORCID,Fu Chaoping²,Hussain Zubair³,Qureshi Muhammad Nasimullah⁴,Farman Saira⁵,Parveen Zahida⁵^ORCID,Zada Amir¹,Nayab Saira⁶^ORCID,Fazil Perveen⁷,Ateeq Muhammad¹,Rehman Gauhar⁸^ORCID,Naeem Mohammad¹,Ibrahim Mohammad¹,Khan Momin¹^ORCID,Khan Waliullah¹

Affiliation:

1. Department of Chemistry, Abdul Wali Khan University, Mardan 23200, Khyber Pakhtunkhwa, Pakistan

2. Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China

3. National Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences, Faisalabad 44000, Pakistan

4. Department of Chemistry, University of Swabi, Anbar, Swabi 23561, Khyber Pakhtunkhwa, Pakistan

5. Department of Biochemistry, Abdul Wali Khan University, Mardan 23200, Pakistan

6. Department of Chemistry, Shaheed Benazir Bhutto University, Sheringal 18050, Upper Dir, Khyber Pakhtunkhwa,Pakistan

7. Department of Chemistry, University of Karachi, Karachi 75270, Pakistan

8. Department of Zoology, Abdul Wali Khan University, Mardan 23200, Khyber Pakhtunkhwa, Pakistan

Funder

Higher Education Commision, Pakistan

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c00529

Reference58 articles.

1. Substituted Benzimidazole Analogues as Potential α-Amylase Inhibitors and Radical Scavengers

2. Indole-3-acetamides: As Potential Antihyperglycemic and Antioxidant Agents; Synthesis, In Vitro α-Amylase Inhibitory Activity, Structure–Activity Relationship, and In Silico Studies

3. Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review

4. Structural elucidation, molecular docking, α-amylase and α-glucosidase inhibition studies of 5-amino-nicotinic acid derivatives

5. Development, Molecular Docking, and In Silico ADME Evaluation of Selective ALR2 Inhibitors for the Treatment of Diabetic Complications via Suppression of the Polyol Pathway

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