A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [<sup>18</sup>F]PFSB and [<sup>18</sup>F]MFSB-Reference-Cited by-同舟云学术

A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [¹⁸F]PFSB and [¹⁸F]MFSB

Published:2023-08-15 Issue:34 Volume:8 Page:31450-31467
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Di Nanni Adriana¹^ORCID,Saw Ran Sing¹,Battisti Umberto M.²^ORCID,Bowden Gregory D.¹³^ORCID,Boeckermann Adam¹,Bjerregaard-Andersen Kaare⁴^ORCID,Pichler Bernd J.¹³,Herfert Kristina¹,Herth Matthias M.²⁵^ORCID,Maurer Andreas¹³^ORCID

Affiliation:

1. Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Röntgenweg 13, 72076 Tübingen, Germany

2. Department of Drug Design and Pharmacology, Faculty of Health and Medicinal Sciences, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark

3. Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University Tübingen, 72076 Tübingen, Germany

4. Department of Antibody Engineering and Biochemistry, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark

5. Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

Funder

H2020 Marie Sklodowska-Curie Actions

Eberhard Karls Universit?t T?bingen

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.3c04292

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1. α-Synuclein in Lewy bodies

2. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

3. Synthetic filaments assembled from C-terminally truncated α-synuclein

4. Discussion of targeting proteins in vivo: in vitro guidelines

5. Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts

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