Mass Spectrometric Imaging of the Brain Demonstrates the Regional Displacement of 6-Monoacetylmorphine by Naloxone

Author:

Teklezgi Belin G.1,Pamreddy Annapurna1,Ntshangase Sphamandla1,Mdanda Sipho1,Singh Sanil D.2,Gopal Nirmala D.3,Naicker Tricia1ORCID,Kruger Hendrik G.1ORCID,Govender Thavendran4ORCID,Baijnath Sooraj1ORCID

Affiliation:

1. Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa

2. Department of Pharmaceutical Science, University of KwaZulu-Natal, Westville Campus, Durban 3629, South Africa

3. Department of Criminology, University of KwaZulu-Natal, Durban 4041, South Africa

4. Department of Chemistry, University of Zululand, Richards Bay 3900, South Africa

Funder

Medical Research Council

Inyuvesi Yakwazulu-Natali

National Research Foundation

Aspen Pharmacare

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Reference56 articles.

1. Management of Substance Abuse. http://www.who.int/substance_abuse/information-sheet/en/ (accessed Sept. 23).

2. Drug Overdose Deaths in the United States Continue to Increase in 2015. https://www.cdc.gov/drugoverdose/epidemic/index.html (accessed Sept. 15).

3. Heroin Overdose Data. https://www.cdc.gov/drugoverdose/data/heroin.html. (accessed Sept. 24).

4. Mechanisms of fatal opioid overdose

5. Differential Roles of Opioid Receptors in Respiration, Respiratory Disease, and Opiate-induced Respiratory Depression

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