Further Investigation of Synaptic Vesicle Protein 2A (SV2A) Ligands Designed for Positron Emission Tomography and Single-Photon Emission Computed Tomography Imaging: Synthesis and Structure–Activity Relationship of Substituted Pyridinylmethyl-4-(3,5-difluorophenyl)pyrrolidin-2-ones
Author:
Affiliation:
1. PET Center, Yale University School of Medicine, New Haven, Connecticut 06520, United States
2. Translational Imaging Neuroscience, AbbVie, North Chicago, Illinois 60064, United States
Funder
National Institute of Biomedical Imaging and Bioengineering
National Institute on Aging
Publisher
American Chemical Society (ACS)
Subject
General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsomega.1c02433
Reference29 articles.
1. PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases
2. Synaptic Vesicles
3. Discovery of Heterocyclic Nonacetamide Synaptic Vesicle Protein 2A (SV2A) Ligands with Single-Digit Nanomolar Potency: Opening Avenues towards the First SV2A Positron Emission Tomography (PET) Ligands
4. Imaging synaptic density in the living human brain
5. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging
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