Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors-Reference-Cited by-同舟云学术

Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors

Published:2019-05-22 Issue:5 Volume:4 Page:8846-8851
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

L’Estrade Elina T.¹²³^ORCID,Hansen Hanne D.²^ORCID,Falk-Petersen Christina¹,Haugaard Anne¹,Griem-Krey Nane¹,Jung Sascha⁴,Lüddens Hartmut⁵^ORCID,Schirmeister Tanja⁴,Erlandsson Maria³,Ohlsson Tomas³,Knudsen Gitte M.²,Herth Matthias M.¹²⁶^ORCID,Wellendorph Petrine¹^ORCID,Frølund Bente¹^ORCID

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

2. Neurobiology Research Unit and CIMBI, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

3. Radiation Physics, Nuclear Medicine Physics Unit, Skånes University Hospital, Barngatan 3, 222 42 Lund, Sweden

4. Institute of Pharmacy & Biochemistry, Johannes Gutenberg University, D-55128 Mainz, Germany

5. Department of Psychiatry and Psychotherapy, Faculty of Health and Medical Sciences, University of Medical Center, D-55131 Mainz, Germany

6. Department of Clinical Physiology, Nuclear Medicine and PET, University Hospital Copenhagen, Rigshospitalet Blegdamsvej 9, 2100 Copenhagen, Denmark

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.9b00434

Reference28 articles.

1. International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidAReceptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

2. GABAA receptors: Subtypes provide diversity of function and pharmacology

3. Subunit Composition, Distribution and Function of GABA-A Receptor Subtypes

4. GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?

5. Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

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