Identification and Optimization of a Novel HIV-1 Integrase Inhibitor-Reference-Cited by-同舟云学术

Identification and Optimization of a Novel HIV-1 Integrase Inhibitor

Published:2022-01-24 Issue:5 Volume:7 Page:4482-4491
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Adu-Ampratwum Daniel¹,Pan Yuhan²,Koneru Pratibha C.³,Antwi Janet¹,Hoyte Ashley C.³,Kessl Jacques⁴^ORCID,Griffin Patrick R.⁵^ORCID,Kvaratskhelia Mamuka²³,Fuchs James R.¹^ORCID,Larue Ross C.²⁶^ORCID

Affiliation:

1. Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States

2. Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States

3. Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado 80045, United States

4. Department of Chemistry & Biochemistry, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States

5. Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States

6. Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, United States

Funder

National Center for Advancing Translational Sciences

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.1c06378

Reference73 articles.

1. Structure-based modeling of the functional HIV-1 intasome and its inhibition

2. Retroviral intasome assembly and inhibition of DNA strand transfer

3. LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells

4. A role for LEDGF/p75 in targeting HIV DNA integration

5. HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots

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1. Pharmacological advances in anti‐retroviral therapy for human immunodeficiency virus‐1 infection: A comprehensive review;Reviews in Medical Virology;2024-03

2. Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity;Molecules;2023-09-19

3. Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole Derivatives, and in Silico Anti-HIV-1 Studies;Bioinorganic Chemistry and Applications;2023-04-21

4. Human immunodeficiency virus integration complexes are active following ordered addition of wild type integrase, viral DNA, and LEDGF/p75;2022-09-19