A Robust and Scalable Process for the Synthesis of Substantially Pure Clarithromycin 9-(<i>E</i>)-Oxime with an Established Control of the (<i>Z</i>)-Isomer Impurity-Reference-Cited by-同舟云学术

A Robust and Scalable Process for the Synthesis of Substantially Pure Clarithromycin 9-(E)-Oxime with an Established Control of the (Z)-Isomer Impurity

Published:2023-03-06 Issue:11 Volume:8 Page:10411-10418
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Chaudhari Kiran¹^ORCID,Gohar Anil¹,Claerhout Stijn²,Ganorkar Rakesh¹

Affiliation:

1. Hikal Ltd, 3A and 3B International Biotech Park Phase II, Hinjewadi, Pune, Maharashtra 411057, India

2. Galapagos NV, Generaal De Wittelaan L11, A3, Mechelen 2800, Belgium

Funder

Gal?pagos

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c08207

Reference22 articles.

1. Azithromycin

2. Chemistry and Biology of Macrolide Antiparasitic Agents

3. In vitro activity and pharmacodynamics of azithromycin and clarithromycin against Streptococcus pneumoniae based on serum and intrapulmonary pharmacokinetics

4. Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms

5. Synthesis and antibacterial activity of O-methyl derivatives of azalide antibiotics: II. 6-OMe derivatives VIA clarithromycin

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1. Development of a Crystallization-Induced Diastereomer Transformation of Oxime Isomers for the Asymmetric Synthesis of (1S,6R)-3,9-Diazabicyclo[4.2.1]nonane;The Journal of Organic Chemistry;2023-08-23