Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease-Reference-Cited by-同舟云学术

Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap–Core Interface of HIV-1 Protease

Published:2018-09-27 Issue:9 Volume:3 Page:12132-12140
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Wong-Sam Andres,Wang Yuan-Fang,Zhang Ying¹,Ghosh Arun K.²^ORCID,Harrison Robert W.,Weber Irene T.^ORCID

Affiliation:

1. RNA Therapeutics Institute and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States

2. Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

Funder

National Institute of General Medical Sciences

Georgia State University

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsomega.8b01683

Reference49 articles.

1. Retroviral proteases and their roles in virion maturation

2. HIV-1 Protease, Reverse Transcriptase, and Integrase Variation

3. ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

4. X-ray crystallographic structure of ABT-378 (Lopinavir) bound to HIV-1 protease

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