In Silico and Structure-Based Assessment of Similar Variants Discovered in Tandem Repeats of BRCT Domains of BRCA1 and BARD1 To Characterize the Folding Pattern
Author:
Affiliation:
1. Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, Maharashtra 410210, India
2. Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, Maharashtra 400094, India
Funder
Department of Biotechnology , Ministry of Science and Technology
Publisher
American Chemical Society (ACS)
Subject
General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c04782
Reference57 articles.
1. Cancer statistics for the year 2020: An overview
2. Centres for Disease Control and Prevention (the CDC, USA). Centres for Disease Control and Prevention (2021).
3. BRCA1 and BRCA2: different roles in a common pathway of genome protection
4. The BRCT Domain Is a Phospho-Protein Binding Domain
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1. In silico investigation on the mutational analysis of BRCA1-BARD1 RING domains and its effect on nucleosome recognition and ubiquitination;Biophysical Chemistry;2023-09
2. Structural dynamics of clinically-reported VUS in the BARD1 ARD-BRCT region to predict the molecular basis of alterations;Journal of Biomolecular Structure and Dynamics;2023-07-07
3. Molecular dynamics simulations reveal the effect of mutations in the RING domains of BRCA1-BARD1 complex and its relevance to the prognosis of breast cancer;Journal of Biomolecular Structure and Dynamics;2023-02-12
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