1. Department of Medical Research, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 622, Taiwan
2. Department of Pharmacy, Chia Nan University of Pharmacy & Science, Tainan 71710, Taiwan
3. School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
4. Department of Otolaryngology-Head and Neck Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 622, Taiwan
5. School of Medicine, Tzu Chi University, Hualien970,Taiwan
6. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung404,Taiwan