Synthesis and Anti-Trypanosoma cruzi Activity of 3-Cyanopyridine Derivatives

Author:

Slafer Brian W.1ORCID,Dessoy Marco A.1ORCID,de Oliveira Ramon G.1ORCID,Mollo Maria C.1ORCID,Lee Eun1ORCID,Matheeussen An2,Maes Louis2,Caljon Guy2ORCID,Ferreira Leonardo L. G.3ORCID,Krogh Renata3ORCID,Andricopulo Adriano D.3ORCID,Cruz Luiza R.4ORCID,Mowbray Charles E.4ORCID,Kratz Jadel M.4ORCID,Dias Luiz C.1ORCID

Affiliation:

1. Institute of Chemistry, State University of Campinas, Campinas 13083-970, São Paulo, Brazil

2. Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, Antwerp 2000, Belgium

3. Laboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos 13566-590, São Paulo, Brazil

4. Drugs for Neglected Diseases initiative, Geneva 1202, Switzerland

Funder

Minist?rio da Sa?de

Direktion f?r Entwicklung und Zusammenarbeit

Ministerie van Buitenlandse Zaken

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

UK International Development

Publisher

American Chemical Society (ACS)

Reference21 articles.

1. WHO. Chagas disease - World Health Organization. https://www.who.int/health-topics/chagas-disease. (accessed June 13, 2023).

2. PAHO. Chagas disease - Pan American Health Organization. https://www.paho.org/en/topics/chagas-disease. (accessed June 13, 2023).

3. Experimental and Clinical Treatment of Chagas Disease: A Review

4. Clinical and pharmacological profile of benznidazole for treatment of Chagas disease

5. New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial

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