Effects of Excipients on the Structure and Dynamics of Filgrastim Monitored by Thermal Unfolding Studies by CD and NMR Spectroscopy
Author:
Affiliation:
1. Centre for Biologics Evaluation, Biologics and Radiopharmaceutical Drugs Directorate, Heath Canada, Ottawa, Ontario K1A 0K9, Canada
Publisher
American Chemical Society (ACS)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.acs.org/doi/pdf/10.1021/acsomega.0c04692
Reference47 articles.
1. Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development
2. The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors.
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4. Cysteine 17 of recombinant human granulocyte-colony stimulating factor is partially solvent-exposed
5. pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor
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