Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 Metalloaminopeptidase-Reference-Cited by-同舟云学术

Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 Metalloaminopeptidase

Published:2011-03-02 Issue:6 Volume:54 Page:1655-1666
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Velmourougane Geetha¹,Harbut Michael B.¹,Dalal Seema²,McGowan Sheena³,Oellig Christine A.³,Meinhardt Nataline¹,Whisstock James C.³,Klemba Michael²,Greenbaum Doron C.¹

Affiliation:

1. Department of Pharmacology, University of Pennsylvania, 433 South University Avenue, 304G Lynch Laboratories, Philadelphia, Pennsylvania 19104-6018, United States

2. Department of Biochemistry, Virginia Polytechnic Institute and State University, 306 Engel Hall, Blacksburg, Virginia 24061, United States

3. Department of Biochemistry and Molecular Biology and Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, VIC 3800, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101227t

Reference59 articles.

1. The global distribution of clinical episodes of Plasmodium falciparum malaria

2. HEMOGLOBIN METABOLISM IN THE MALARIA PARASITE PLASMODIUM FALCIPARUM

3. Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems

4. Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity

5. Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

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