Potent Derivatives of Glucagon-like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration-Reference-Cited by-同舟云学术

Potent Derivatives of Glucagon-like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration

Published:2000-04-18 Issue:9 Volume:43 Page:1664-1669
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Knudsen Lotte B.¹,Nielsen Per F.¹,Huusfeldt Per O.¹,Johansen Nils L.¹,Madsen Kjeld¹,Pedersen Freddy Z.¹,Thøgersen Henning¹,Wilken Michael¹,Agersø Henrik¹

Affiliation:

1. Departments of Molecular Pharmacology, Protein Chemistry, Medicinal Chemistry, Assay & Cell Technology, and Pharmacokinetics, Health Care Discovery and Preclinical Development, Novo Nordisk A/S, Novo Park, DK-2760 Maaloev, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9909645

Reference30 articles.

1. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

2. Subcutaneous Injection of the Incretin Hormone Glucagon-Like Peptide 1 Abolishes Postprandial Glycemia in NIDDM

3. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients

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